Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering

• Eric J. N. Helfrich,
• Geng-Min Lin,
• Christopher A. Voigt and
• Jon Clardy

Beilstein J. Org. Chem. 2019, 15, 2889–2906, doi:10.3762/bjoc.15.283

• a result of the inherent differences between these biosynthetic machineries. In modular assembly lines, each individual domain is responsible for one defined biosynthetic transformation, while TCs rather act as chaperones [10] to guide oligoprenyl pyrophosphate precursors through a cascade of

Assembly of synthetic Aβ miniamyloids on polyol templates

• Sebastian Nils Fischer and
• Armin Geyer

Beilstein J. Org. Chem. 2015, 11, 2646–2653, doi:10.3762/bjoc.11.284

• peptides, which are linked to the template as boronic esters. A shape-persistent template is necessary which offers the correct spacing between Aβ strands to allow for their preferred cross-β-sheet contacts. The modular assembly of peptides on a template is expected to access synthetic Aβ miniamyloids with

Some aspects of radical chemistry in the assembly of complex molecular architectures

• Béatrice Quiclet-Sire and
• Samir Z. Zard

Beilstein J. Org. Chem. 2013, 9, 557–576, doi:10.3762/bjoc.9.61

• tedious by more traditional routes. The possibility of iterating the radical addition allows for a convergent and highly modular assembly of complex scaffolds. The three successive additions outlined in Scheme 8 and leading to 37 illustrate nicely this approach [25]. One xanthate, 36, and three different

Design and synthesis of quasi-diastereomeric molecules with unchanging central, regenerating axial and switchable helical chirality via cleavage and formation of Ni(II)–O and Ni(II)–N coordination bonds

• Vadim A. Soloshonok,
• José Luis Aceña,
• Hisanori Ueki and
• Jianlin Han

Beilstein J. Org. Chem. 2012, 8, 1920–1928, doi:10.3762/bjoc.8.223

• framework of our recently described methodology for applying a new generation of nucleophilic glycine equivalents [27][28][29][30][31][32] to a general asymmetric synthesis of α-amino acids [33][34][35][36][37][38]. In this manner, modular assembly of achiral C2-symmetric pentadentate ligands 12 was carried

Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

• Hiroki Oguri,
• Haruki Mizoguchi,
• Hideaki Oikawa,
• Aki Ishiyama,
• Masato Iwatsuki,
• Kazuhiko Otoguro and
• Satoshi Ōmura

Beilstein J. Org. Chem. 2012, 8, 930–940, doi:10.3762/bjoc.8.105

• , Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan 10.3762/bjoc.8.105 Abstract By emulating the universal biosynthetic strategy, which employs modular assembly and

• divergent cyclizations, we have developed a four-step synthetic process to yield a collection of natural-product-inspired scaffolds. Modular assembly of building blocks onto a piperidine-based manifold 6, having a carboxylic acid group, was achieved through Ugi condensation, N-acetoacetylation and

• undertaken. Keywords: chemical diversity; divergent cyclization; indole alkaloids; modular assembly; rhodium-catalyzed cyclization–cycloaddition; skeletal and stereochemical diversity; Introduction Biologically intriguing natural products often possess cyclic scaffolds bearing dense arrays of functional

Calix[4]arene-click-cyclodextrin and supramolecular structures with watersoluble NIPAAM-copolymers bearing adamantyl units: “Rings on ring on chain”

• Bernd Garska,
• Monir Tabatabai and
• Helmut Ritter

Beilstein J. Org. Chem. 2010, 6, 784–788, doi:10.3762/bjoc.6.83

• progress in the field of supramolecular chemistry is based on click chemistry, a versatile and powerful tool that permits the modular assembly of new molecular entities [6][7]. Both CDs as well as calixarenes have already been modified by click chemistry [8][9][10][11][12][13][14]. However, the coupling of